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Total synthesis of cis and trans-hydroxyglimepiride: active metabolite of glimepiride |
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| Authors: | Mukund K GurjarSiddhartha R Chaudhuri Shreerang V JoshiLalji K Gediya Prasad V RanadeSuresh M Kadam Sanjay J Naik |
| Affiliation: | a National Chemical Laboratory, Pune 411008, India b Chemical Process Research Laboratory, USV Ltd, Govandi, Mumbai 400 088, India |
| Abstract: | Syntheses of trans-hydroxyglimepiride 2b, a human metabolite of the blood glucose lowering agent glimepiride 1 and its corresponding cis-stereoisomer 2a, are described. |
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