Practical, efficient, stereoselective, formal synthesis of (2R,3R,4R)-3-hydroxy-4-methylproline |
| |
Authors: | Sadagopan Raghavan S. Ramakrishna Reddy |
| |
Affiliation: | Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
Abstract: | A highly efficient and stereoselective synthesis of (2R,3R,4R)-HMP is disclosed employing the sulfinyl group as an internal nucleophile to functionalize an olefin in the key step of the reaction sequence. The proline ring is elaborated by a (4C+N) cyclization. |
| |
Keywords: | sulfoxide hydroxymethyl proline bromohydrin stereoselective |
本文献已被 ScienceDirect 等数据库收录! |
|