Synthetic studies on ecteinascidin 743: asymmetric synthesis of the versatile amino acid component |
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Authors: | Wei JinRobert M Williams |
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Institution: | Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA |
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Abstract: | The asymmetric synthesis of the modified tyrosine derivative as a basic building block for the ecteinascidin and safracin family of antitumor alkaloids has been achieved in nine steps and 39% overall yield. |
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