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New selenyl linker for solid-phase synthesis of dehydropeptides |
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| Authors: | Kazuhiko Nakamura Yuki Ohnishi Eiji Horikawa Takeo KonakaharaMasato Kodaka Hiroaki Okuno |
| Institution: | a National Institute of Advanced Industrial Science and Technology (AIST), Central 6-9, Higashi 1-1-1, Tsukuba, Ibaraki 305-8566, Japan b Faculty of Industrial Science and Technology, Tokyo University of Science 2641 Yamazaki, Noda, Chiba 278-8510, Japan |
| Abstract: | A novel linker possessing selenocyanate and masked carboxylic acid was developed for the solid-phase synthesis of dehydropeptides. This linker was used to demonstrate the synthesis of the model compound of RGD-conjugated dehydropeptide. |
| Keywords: | dehydropeptide solid-phase synthesis selenyl linker RGD-conjugate |
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