Synthesis of N-substituted 1,2,5-thiadiazolidine and 1,2,6-thiadiazinane 1,1-dioxides from primary amines |
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| Authors: | Paul D JohnsonDonna L Romero |
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| Institution: | a Medicinal Chemistry, Pharmacia, Kalamazoo, MI 49001, USA
b Alma College, Alma MI 48801, USA |
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| Abstract: | Alkyl and aryl N-substituted 1,2,5-thiadiazolidine and 1,2,6-thiadiazinane 1,1-dioxides 6 were synthesized in good yields from the reaction of sulfuryl chloride with 2-chloroethylamine or 3-chloropropylamine hydrochlorides, respectively, followed by treatment with a primary amine and triethylamine, and ring closure with K2CO3 in DMSO. |
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