Extending the possibility of an N-Troc-protected sialic acid donor toward variant sialo-glycoside synthesis |
| |
| Authors: | Hiromune Ando Yusuke KoikeHideharu Ishida Makoto Kiso |
| |
| Institution: | a Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
b CREST, Japan Science and Technology Corporation (JST), 1-1 Yanagido, Gifu 501-1193, Japan |
| |
| Abstract: | The potential of an N-Troc-protected sialic acid donor, equipped with phenylsulfenyl functionality as a leaving group, has been explored. As a result, the entitled donor was proven to be highly reactive and to have broad applicability toward the synthesis of variant sialo-glycans, which have N-glycolyl, de-N-acetyl, 1,5-lactam and 8-O-sulfo sialic acid analogs. |
| |
| Keywords: | N-Troc group sialidation sialic acid analogs |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
