|
|||||
|
|
Cyclic ketones and substituted α-keto acids as alternative substrates for novel Biginelli-like scaffold syntheses |
|
| Authors: | Matthew M Abelman Stephen C SmithDonald R James |
| Affiliation: | a Signature BioScience, Inc., 1240 South 47th Street, Richmond, CA 94804, USA b Syngenta Ltd., Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK |
| Abstract: | The reactions of benzocyclic ketones and α-ketoacids as carbonyl components in the Biginelli reaction were investigated. These unusual Biginelli substrates furnished novel drug-like dihydropyrimidinone scaffolds suitable for further elaboration. |
| Keywords: | Biginelli α-keto acid dihydropyrimidinone pyrrolidinium tosylate |
| 本文献已被 ScienceDirect 等数据库收录！ | |