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Synthesis of (15S,16S,21R)-4-deoxyrollicosin analog |
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| Authors: | Jeng-Lin Lee Chi-Fong LinLing-Yu Hsieh Wan-Ru LinHuey-Fen Chiu Yang-Chang WuKun-Sheng Wang Ming-Jung Wu |
| Institution: | a School of Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC b Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC c Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC |
| Abstract: | Synthesis of 4-deoxy rollicosin analog 2 was completed in nine steps, which was based on palladium-catalyzed coupling of two building blocks 3 and 4. Lactone 3 was synthesized from 5-hexyn-1-ol, and vinyl iodide 4 was accessed from l-glutamate and 1-hexyne. |
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