Dichloroborane-dioxane: an exceptional reagent for the preparation of alkenyl- and alkylboronic acids |
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Authors: | Kanth VB Josyula Peng GaoChris Hewitt |
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Institution: | Aldrich Chemical Company, Inc., 1001 W. Saint Paul Avenue, Milwaukee, WI 53233, USA |
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Abstract: | Terminal alkynes and alkenes were conveniently hydroborated to the corresponding alkenyl- and alkyldichloroboranes using dichloroborane-dioxane in dichloromethane. These dichloroboranes were hydrolyzed by water to the corresponding alkenyl- and alkylboronic acids in moderate to good yields. With terminal alkenes and alkynes boron was predominantly attached to terminal carbon. Alkynes gave exclusively trans-vinylboronic acids. |
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