Synthesis of (R) and (S) enantiomers of Fmoc-protected 1,2,4-oxadiazole-containing β-amino acids from Fmoc-(R)-β-HAsp(OtBu)-OH期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Synthesis of (R) and (S) enantiomers of Fmoc-protected 1,2,4-oxadiazole-containing β-amino acids from Fmoc-(R)-β-HAsp(OtBu)-OH

Authors:	Abdallah HamzéJean-François Hernandez Jean Martinez

Institution:	Laboratoire des Aminoacides Peptides et Protéines, CNRS UMR 5810, Universités Montpellier I et II, Faculté de Pharmacie, 15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France

Abstract:	Fmoc-(R)-β-HomoAsp(OtBu)-OH was used for the synthesis of both (R) and (S) enantiomers of various Fmoc-protected 3-substituted 1,2,4-oxadiazole-containing β³-amino acids. The 1,2,4-oxadiazole heterocycle was formed using sodium acetate, a Fmoc-compatible and efficient catalyst for cyclodehydration.

Keywords:	β³-amino acid 1 2 4-oxadiazole Fmoc
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