A practical approach for the chemical synthesis of 2′-deoxyguanosine-C8 adducts with mutagenic/carcinogenic amino- or nitro-arenes |
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| Authors: | Takeji Takamura-Enya Satoko IshikawaMasataka Mochizuki Keiji Wakabayashi |
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| Institution: | a Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, Japan
b Kyoritu College of Pharmacy, 5-30 Shibakoen 1-chome, Minato-ku, Tokyo, Japan |
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| Abstract: | Synthetic methods for the preparation of 2′-deoxyguanosine-C8 (dG-C8) adducts with several mutagenic and carcinogenic amino- or nitro-arenes were developed using the palladium-mediated cross-coupling reaction of protected 8-amino-dG with bromoarenes in around 80% yields, followed by conventional deprotection procedures. This approach can be applied to preparation of a variety of authentic dG-C8 adducts with amino or nitro-arenes. |
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| Keywords: | dG-C8 adducts arylamination reaction |
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