Stereoselective synthesis of the α-glucosidase inhibitor nectrisine |
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| Authors: | Alison N Hulme Charles H Montgomery |
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| Institution: | School of Chemistry, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK |
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| Abstract: | The α-glucosidase inhibitor nectrisine was synthesised in 12 steps (31% overall yield) starting from d-serine. The three contiguous stereocentres of this iminosugar were introduced via a highly diastereoselective boron mediated glycolate aldol reaction. |
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| Keywords: | iminosugars glycolate aldol glycosidase inhibitors |
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