An allylation-metathesis sequence as a convergent strategy towards enantiopure equivalents of highly functionalized cyclic dienes |
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| Authors: | Laurence de FaysJean-Michel Adam Léon Ghosez |
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| Institution: | a Institut Européen de Chimie et Biologie, c/o ENSCPB, 16 avenue Pey Berland, 33607 Pessac Cedex, France
b Departement de Chimie, Université Catholique de Louvain, place L. Pasteur, B-1348 Louvain-la-Neuve, Belgium |
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| Abstract: | Highly enantioenriched equivalents of cyclic dienes have been readily prepared by asymmetric allylation of unsaturated aldehydes using a chiral allyltitanium reagent, followed by a ring-closing metathesis. The resulting β-hydroxy allylsilanes react stereoselectively with a wide variety of electrophilic reagents. |
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