A concise approach to 5-substituted-4-pyrones from kojic acid |
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| Authors: | Tomoyuki KaminoKouji Kuramochi Susumu Kobayashi |
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| Affiliation: | a Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
b Frontier Research Center for Genomic Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan |
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| Abstract: | A concise approach to 5-substituted-4-pyrones is described. This approach is based on manipulation of the 5-hydroxy group of readily available kojic acid. A number of 5-substituted-4-pyrones were synthesized from kojic acid utilizing Heck reaction, Suzuki coupling and Stille coupling. |
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