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New environmentally friendly solvent free synthesis of dihydropyrimidinones catalysed by N-butyl-N,N-dimethyl-α-phenylethylammonium bromide |
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| Authors: | K. Rosi ReddyCh. Venkateshwar Reddy M. MaheshP.V.K. Raju V.V. Narayana Reddy |
| Affiliation: | Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | N-Butyl-N,N-dimethyl-α-phenylethylammonium bromide catalyzes efficiently the three component condensation reaction of an aromatic aldehyde, a β-keto ester and urea/thiourea under solvent free conditions at 100°C to afford the corresponding dihydropyrimidinone in high yield. |
| Keywords: | N-butyl-N,N-dimethyl-α-phenylethylammonium bromide β-ketoesters Biginelli reaction dihydropyrimidinones |
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