Application of tandem Ugi reaction/ring-closing metathesis in multicomponent synthesis of unsaturated nine-membered lactams |
| |
Authors: | Luca Banfi Andrea BassoGiuseppe Guanti Renata Riva |
| |
Institution: | Dipartimento di Chimica e Chimica Industriale, via Dodecaneso 31, I-16146 Genova, Italy |
| |
Abstract: | A new straightforward entry into unsaturated nine-membered lactams of potential use as external reverse turn inducers was developed. It is based on an Ugi multicomponent reaction using two unsaturated substrates, followed by highly stereoselective ring-closing metathesis (RCM). The synthesis of a nine-membered secondary lactam by RCM is reported for the first time. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |