| Synthesis and molecular modeling study of Cu(Ⅱ) complexes derived from 2-(diphenylmethylene)hydrazinecarbothioamide derivatives with cholinesterase inhibitory activities |
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| 作者姓名： | Yi Chen Chan Abdussalam Salhin Mohamed Ali Melati Khairuddean Kooi Yeong Khaw Vikneswaran Murugaiyah Alireza Basiri |
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| 作者单位： | School of Chemical Sciences,Universiti Sains Malaysia;Discipline of Pharmacology,School of Pharmaceutical Sciences,Universiti Sains Malaysia |
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| 基金项目： | Universiti Sains Malaysia -Science Fund Grant No.1001/PK1M1A/823003 and RU Grant No. 1001/PKIMIA/811196 for the financial support of this work |
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| 摘 要： | Thiosemicarbazones of 2-amino-5-chlorobenzophenone and 3-aminobenzophenone（L1-L4） have been synthesized and their Cu（Ⅱ） complexes（1-4） were afforded via coordination with cupric chloride.All these compounds were characterized by UV-vis and IR spectroscopy together with CHN elemental analysis.NMR spectroscopy was also applied to characterize the ligands.In vitro chohnesterase inhibitory assays for the complexes（1-4） showed IC50 values less than 10μmol/L,with complex 1 exhibiting the most activity,IC50=2.15μmol/L and 2.16μmol/L for AChE and BuChE,respectively. Molecular modeling simulation revealed the binding interaction template for complex 1 with the AChE and BuChE receptors.In DPPH assay,the complexes also showed more in vitro antioxidant activities in comparison to their parent ligands.
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| 关 键 词： | Thiosemicarbazone Cu(Ⅱ) complex Cholinesterase Molecular modeling |
| 收稿时间： | 29 January 2013 |
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