Highly enantioselective synthesis of a fluorescent amino acid |
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| Authors: | P ter Kele, Guodong Sui, Qun Huo,Roger M. Leblanc |
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| Affiliation: | Center for Supramolecular Science and Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33124, USA |
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| Abstract: | A high enantiomeric excess (>99.5%) synthesis of 2-amino-3-(7-methoxy-4-coumaryl) propionic acid (Amp) is described. The two step synthesis route of this non-proteinogenic amino acid includes an oxazinone derivative as glycine enolate, which is alkylated with the fluorogenic group. |
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