Diversity oriented and chemoenzymatic synthesis of densely functionalized pyrrolidines through a highly diastereoselective Ugi multicomponent reaction |
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Authors: | Cerulli Valentina Banfi Luca Basso Andrea Rocca Valeria Riva Renata |
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Institution: | Department of Chemistry and Industrial Chemistry, University of Genova, via Dodecaneso 31, 16146, Genova, Italy. |
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Abstract: | A highly diastereoselective Ugi reaction involving a chiral cyclic imine, two enantiomerically pure isocyanides and various carboxylic acids was employed for the synthesis of polyfunctionalized pyrrolidines. Both chiral substrates have been efficiently prepared by chemoenzymatic methodologies from readily available achiral substrates. This highly convergent approach can find an application in the fragment-based drug discovery process. |
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