Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies |
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| Authors: | Hernández-Rocamora Víctor M Reulen Sanne W A de Waal Bas Meijer E W Sanz Jesus M Merkx Maarten |
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| Institution: | Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Avda Universidad s/n, Elche 03202, Spain. |
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| Abstract: | A modular self-assembly strategy is presented that allows the non-covalent synthesis of multivalent protein dendrimers using the strong interaction between choline-functionalized dendrimers and the choline binding protein C-LytA. Choline dendrimers displaying fusion proteins of C-LytA and the collagen binding protein CNA35 represent attractive multivalent targeting ligands for collagen imaging. |
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