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Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues
Authors:Singh A Jonathan  Razzak Mina  Teesdale-Spittle Paul  Gaitanos Thomas N  Wilmes Anja  Paterson Ian  Goodman Jonathan M  Miller John H  Northcote Peter T
Institution:Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.
Abstract:Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.
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