Determination of acipimox in capsules by differential pulse polarography |
| |
Authors: | Astrid Michelitsch Petra Muhr Manfred Schubert-Zsilavecz Werner Likussar |
| |
Affiliation: | (1) Institut für Pharmazeutische Chemie, Universität Graz, Schubertstrasse 1, A-8010 Graz, Austria |
| |
Abstract: | A differential pulse polarographic (DPP) method has been developed for the determination of acipimox in its pharmaceutical formulations. Using Sörensen buffer pH 6.0 as supporting electrolyte a single, irreversible peak occurred at –0.79 V vs an Ag/AgCl reference electrode. The peak height vs concentration plot was found to be linear over the range of 10–6 to 6 × 10–4 mol/l. The detection limit is 60ng/ml. The analysis of a series of 10 Olbetam® 250 mg capsules showed an overall standard deviation of ± 4.18 mg and a Srel of ± 1.66%, respectively. |
| |
Keywords: | acipimox determination of DPP, polarography |
本文献已被 SpringerLink 等数据库收录! |