Rubbery wound closure adhesives. I. design,synthesis, characterization,and testing of polyisobutylene‐based cyanoacrylate homo‐ and co‐networks |
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| Authors: | Istvan Szanka Amalia Szanka Sinan ?en Nihan Nugay Joseph P Kennedy |
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| Institution: | 1. Institute of Polymer Science, The University of Akron, Akron, Ohio;2. Polymer Chemistry Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary;3. Department of Polymer Engineering, Yalova University, Yalova, Turkey;4. Department of the Chemistry, Polymer Research Center, Bo?azi?i University, ?stanbul, Turkey |
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| Abstract: | Novel rubbery wound closures containing various proportions and molecular weights of polyisobutylene (PIB) and poly(2‐octyl cyanoacrylate) P(OctCA)] for potential clinical use were designed, synthesized, characterized, and tested. Homo‐networks were prepared by crosslinking 3‐arm star‐shaped PIBs fitted with terminal cyanoacrylate groups, Ø(PIB‐CA)3], and co‐networks by copolymerizing Ø(PIB‐CA)3 with OctCA using N‐dimethyl‐p‐toluidine (DMT). Neat Ø(PIB‐CA)3, and Ø(PIB‐CA)3/OctCA blends, upon contact with initiator, polymerize within seconds to optically transparent strong rubbery co‐networks, Ø(PIB‐CA)3‐co‐P(OctCA). Homo‐ and co‐network formation was demonstrated by sol/gel studies, and structures and properties were characterized by a battery of techniques. The Tg of P(OctCA) is 58 °C by DSC, and 75 °C by DMTA. Co‐networks comprising 25% Ø(PIB‐CA)3 (Mn = 2400 g/mol) and 75% P(OctCA) are stronger and more extensible than skin. Short and long term creep studies show co‐networks exhibit high dimensional stability and <6% creep strain at high loading. When deposited on porcine skin co‐networks yield hermetically‐adhering clear rubbery coatings. Strips of porcine skin coated with co‐networks could be stretched and twisted without compromising membrane integrity. The co‐network is nontoxic to L‐929 mouse fibroblasts. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 1640–1651 |
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| Keywords: | adhesives cyanoacrylate network polyisobutylene rubber wound dressing |
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