Synthesis,physicochemical characteristics,and biocompatibility of self‐assemble polymers bearing guanine,cytosine, uracil,and thymine moieties |
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| Authors: | Jungwoon Jung Jinseok Lee Brian J. Ree Heesoo Kim Ik Jung Kim Jung Ran Kim Moonhor Ree |
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| Affiliation: | 1. Department of Chemistry, Division of Advanced Materials Science, Pohang Accelerator Laboratory, Polymer Research Institute, and BK School of Molecular Science, Pohang University of Science and Technology, Pohang, Republic of Korea;2. Department of Microbiology, Dongguk Medical Institute, Dongguk University College of Medicine, Gyeongju, Republic of Korea;3. Department of Pathology, Dongguk Medical Institute, Dongguk University College of Medicine, Gyeongju, Republic of Korea |
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| Abstract: | We synthesized chemically well‐defined brush (i.e., comb‐like) polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends. The polymers were stable up to 220 °C and were readily solution‐processable, yielding high‐quality films. Interestingly, the brush polymers favorably self‐assembled to form molecular multibilayer structures stabilized by hydrogen bonding interactions among the nucleobase moieties at the bristle ends, which provided nucleobase‐rich surfaces. The multibilayer‐structured polymer films showed high water affinity. They also displayed selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, and exhibited good biocompatibility in mice. The brush polymer DNA‐mimicking comb‐like polymers are suitable as biomaterials and in protein separation applications. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 1151–1160 |
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| Keywords: | biocompatibility biomaterials biomimetic synthesis self‐assembly thin films |
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