pH‐ and β‐cyclodextrin‐responsive micelles based on polyaspartamide derivatives as drug carrier |
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| Authors: | Huan Yu Jian Sun Yunti Zhang Guangyan Zhang Yanfeng Chu Renxi Zhuo Xulin Jiang |
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| Affiliation: | 1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China;2. Hubei Provincial Key Laboratory of Green Materials for Light Industry, Department of Light Industry, Hubei University of Technology, Wuhan 430068, People's Republic of China |
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| Abstract: | A novel kind of graft polymer poly(aspartic acid)‐ethanediamine‐g‐adamantane/methyloxy polyethylene glycol (Pasp‐EDA‐g‐Ad/mPEG) was designed and synthesized for drug delivery in this study. The chemical structure of the prepared polymer was confirmed by proton NMR. The obtained polymer can self‐assemble into micelles which were stable under a physiological environment and displayed pH‐ and β‐cyclodextrin (β‐CD)‐responsive behaviors because of the acid‐labile benzoic imine linkage and hydrophobic adamantine groups in the side chains of the polymer. The doxorubicin (Dox)‐loaded micelles showed a slow release under physiological conditions and a rapid release after exposure to weakly acidic or β‐CD environment. The in vitro cytotoxicity results suggested that the polymer was good at biocompatibility and could remain Dox biologically active. Hence, the Pasp‐EDA‐g‐Ad/mPEG micelles may be applied as promising controlled drug delivery system for hydrophobic antitumor drugs. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 1387–1395 |
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| Keywords: | conjugated polymers cyclodextrin‐responsive drug delivery system micelles nanoparticles pH‐responsive polyaspartamide polymeric micelles stimuli‐sensitive polymers |
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