Crystallization of chiral compounds 4. Simple physical model for reconstruction of post-eutectic DSC traces for melting of binary enantiomeric mixtures |
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Authors: | D. V. Zakharychev A. A. Bredikhin |
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Affiliation: | (1) A. E. Arbuzov Institute of Organic and Physical Institute, Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088 Kazan, Russian Federation;(2) Kazan Scientific Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088 Kazan, Russian Federation |
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Abstract: | A theoretical model reproducing qualitative and quantitative characteristics of DSC traces for melting of eutectic enantiomeric mixtures was proposed. The method for reconstruction of an idealized trace from a fragment of the real experimental melting curve was developed. When studying a sample of intermediate enantiomeric composition, the reconstruction of the trace makes it possible to avoid ambiguity in determination of the liquidus temperature, determine the melting temperature for an enantiopure compound, and estimate the composition of the sample. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1288–1293, July, 2007. |
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Keywords: | differential scanning calorimetry phase diagram of melting enantiomers enantiomeric composition mephenesin |
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