| SOLID PHASE SYNTHESIS OF ISOXAZOLINES |
| |
| 作者姓名： | SUN Weimin LUO Juntao HUANG Wenqiang State Key Laboratory of Functional Polymer Material for Adsorption and Separation Institute of Polymer Chemistry Nankai University Tianjin China |
| |
| 作者单位： | SUN Weimin LUO Juntao HUANG Wenqiang State Key Laboratory of Functional Polymer Material for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China |
| |
| 基金项目： | NNSFC (20074017,29844001) and Visiting Scholar Foundation of Key Lab. In University |
| |
| 摘 要： | 1. INTRODUCTION A solid phase organic synthesis (SPOS) has increasingly attracted chemist抯 attention over the past decades 1~3]. It was found that the compounds with biological activity are mostly derived from heterocycle structures. It is therefore no…
|
SOLID PHASE SYNTHESIS OF ISOXAZOLINES |
| |
| SUN Weimin LUO Juntao HUANG Wenqiang State Key Laboratory of Functional Polymer Material for Adsorption and Separation,Institute of Polymer Chemistry,Nankai University,Tianjin ,China.SOLID PHASE SYNTHESIS OF ISOXAZOLINES[J].离子交换与吸附(英文版),2002(1). |
| |
| Authors: | SUN Weimin LUO Juntao HUANG Wenqiang State Key Laboratory of Functional Polymer Material for Adsorption and Separation |
| |
| Institution: | SUN Weimin LUO Juntao HUANG Wenqiang State Key Laboratory of Functional Polymer Material for Adsorption and Separation,Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China |
| |
| Abstract: | The solid-phase synthesis of isoxazolines on 2-polystyrylsulfonamidoethanol resin is reported. 2-Polystyrylsulfonamidoethanol resin 1 was reacted with acryloyl chloride to afford 2-polystyrylsulfonylamidoethyl acrylate resin 2, which was further reacted with brominated aldoximes by 3 2] cycloaddition to give isoxazoline resin 4. Resin 4 was treated with aqueous 6 mol/L HCl solution to obtain isoxazolines in good yield and purity. |
| |
| Keywords: | Solid phase synthesis 2-Polystyrylsulfonamidoethanol Isoxazoline |
| 本文献已被 CNKI 等数据库收录！ |
