含分子内氢键的苯硫酚在水相中的Michael加成反应

苯硫酚的巯基是一个较强的亲核基团，对α，β-不饱和双键的Michael加成反应已有报道．但是当巯基的邻位存在与其形成氢键的基团时，如果按文献条件进行反应，或者反应无法进行，或者要使用反应条件苛刻的丁基锂，或者使用吡啶等毒性较大的反应溶剂，而且产率较低．本文选择

Michael Addition Reaction of Thiophenol with Intramolecular Hydrogen Bond in Aqueous Medium

The method of Michael addition reaction of thiophenol with intramolecular hydrogen bond in an aqueous medium was reported. The aqueous reactive medium includes saturated sodium bicarbonate solution and catalytic amount of tetrabutylammonium bisulfate. 2-Hydroxythiophenol,2-aminothiophenol,2-carboxythiophenol,ethyl acrylate and arcylonitrile were selected as model molecules to demonstrate the method. It is found that the reaction can be accomplished rapidly at room temperature with a high yield,and no mercapto-coupling byproduct formed.