Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos |
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| Authors: | Doaa Abu Saleh Jukka Niskanen Yanming Xue Dmitri Golberg Françoise M. Winnik Alejandro Sosnik |
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| Affiliation: | 1. Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa, Israel;2. Laboratory of Polymer Chemistry, Department of Chemistry, A.I. Virtasen aukio 1, P.O. Box 55, 00014, University of Helsinki, Helsinki, Finland;3. International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Japan;4. Queensland University of Technology, Brisbane, Qld, Australia;5. Département de Chimie, Université de Montréal, CP 6128, Succursale Centre-Ville, Montréal, QC, Canada |
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| Abstract: | We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features. |
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| Keywords: | Core-shell amphiphilic hybrid nanomaterials Boron nitride nanotubes Polymeric micelles Drug encapsulation Curcumin |
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