Some observations on the reaction of cysteine with o-phthalaldehyde |
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| Affiliation: | 1. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia;2. Department of Chemistry, College of Science & Arts, King Abdulaziz University, P.O. Box 344, Rabigh, 21911, Saudi Arabia;3. Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria, 21321, Egypt;4. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assuit, 71524, Egypt;5. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh, 11451, Saudi Arabia;6. Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt;1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India;2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India;3. Centre for Advanced Materials & Industrial Chemistry (CAMIC), School of Science, RMIT University, GPO Box 2476, Melbourne 3001, Australia |
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| Abstract: | Cysteine can behave simultaneously as an amino compound and thiol in the reaction with o-phthalaldehyde to produce a fluorescent compound. At room temperature, no reaction is observed, but a very stable compound (λexc = 364 nm, λem = 424 nm) is slowly formed upon heating. Constant fluorescence intensity is achieved after heating at 50°C for 3 h, remaining unchanged for at least 3 h when cooled. |
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