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Cells anchored upon a thin organic film with different nano-mechanical properties |
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| Authors: | Chih-Ling Huang Jiunn-Der Liao Yi-Te Wu Chou-Ching K. Lin |
| Affiliation: | a Department of Materials Science and Engineering, National Cheng Kung University, No.1, University Road, Tainan 70101, Taiwan b Center for Micro/Nano Science and Technology, National Cheng Kung University, No.1, University Road, Tainan 70101, Taiwan c Department of Mechanical Engineering, National Cheng Kung University, No.1, University Road, Tainan 70101, Taiwan d Department of Neurology, National Cheng Kung University, No.1, University Road, Tainan 70101, Taiwan |
| Abstract: | By applying dynamic contact module and particular measurement of phase angles, harmonic contact stiffness (S) along with the measured displacement (D) of different self-assembled monolayers (SAMs) adsorbed on Au can be distinguished. The relatively ordered and hydrophobic ODT and DDT molecules adsorbed on Au form high contact stiffness, which are presumably unfavorable substrates for a cell to adhere upon. Short-chain MUA molecules adsorbed on Au provides a hydrophilic characteristic with a relatively low contact stiffness, which may significantly promote cell adhesion. It is, therefore, estimated that the behavior of a cell adhered on SAMs/Au is correlated not only with their outermost chemical species but also with a proper dS/dD matrix acting as a cushion. |
| Keywords: | 62.25.&minus g |
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