Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency |
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| Authors: | Yamasaki Kosuke Sakuma Yasunobu Sasaki Junya Matsumoto Ken-ichiro Anzai Kazunori Matsuoka Keisuke Honda Chikako Tsukada Masamichi Endo Kazutoyo Enomoto Shuichi |
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| Affiliation: | (1) School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki Kanagawa, 214-8571, Japan;(2) Department of Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida Tokyo, 194-8543, Japan;(3) Research Center for Charged Particle Therapy, National Institute of Radiological Science, 4-9-1 Anagawa, Inage-ku Chiba-shi, Chiba 263-8555, Japan;(4) Radioisotope Technology Division, Cyclotron Center, The Institute of Physical and Chemical Research (RIKEN), Wako Saitama, 351-0106, Japan;(5) Present address: Department of Analytical Chemistry, School of Pharmacy, Okayama University, 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan; |
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| Abstract: | The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of 59Fe and 65Zn in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver. |
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