| Synthesis,Crystal Structure and Anticancer Property of （Z）-N-（4-Bromo-5-ethoxy-3,5-dimethyl-furan-2（5H）-ylidene）-4-methylbenzenesulfonamide |
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| 引用本文： | ZHANG,Shi-Jie HU,Wei-Xiao. Synthesis,Crystal Structure and Anticancer Property of （Z）-N-（4-Bromo-5-ethoxy-3,5-dimethyl-furan-2（5H）-ylidene）-4-methylbenzenesulfonamide[J]. 结构化学, 2010, 29(8): 1275-1279 |
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| 作者姓名： | ZHANG Shi-Jie HU Wei-Xiao |
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| 作者单位： | College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, China |
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| 摘 要： | The novel title compound(Z)-N-(4-bromo-5-ethoxy-3,5-dimethylfuran-2(5H)-yli-dene)-4-methylbenzenesulfonamide 1(C15H18BrNO4S) has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2,and characterized by mp,IR,1H NMR,EIMS,ESIHRMS and single-crystal X-ray diffraction.It crystallizes in mono-clinic,space group P21/c with a = 11.714(5),b = 14.106(5),c = 10.402(4) ,β = 97.298(8)°,V = 1704.9(12) 3,Mr = 388.27,Z = 4,Dc = 1.513 g/cm3,μ(MoKα) = 2.549 mm-1,F(000) = 792,the final R = 0.033 and wR = 0.062 for 3098 observed reflections(Ⅰ 2σ(Ⅰ)).
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| 关 键 词： | 晶体结构 甲基呋喃 乙氧基 合成 小时 单晶X射线衍射 性质 抗癌 |
Synthesis, Crystal Structure and Anticancer Property of (Z)-N-(4-Bromo-5-ethoxy-3,5-dimethyl-furan-2(5H)-ylidene)-4-methylbenzenesulfonamide |
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| ZHANG Shi-Jie,HU Wei-Xiao. Synthesis, Crystal Structure and Anticancer Property of (Z)-N-(4-Bromo-5-ethoxy-3,5-dimethyl-furan-2(5H)-ylidene)-4-methylbenzenesulfonamide[J]. Chinese Journal of Structural Chemistry, 2010, 29(8): 1275-1279 |
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| Authors: | ZHANG Shi-Jie HU Wei-Xiao |
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| Abstract: | The novel title compound (Z)-N-(4-bromo-5-ethoxy-3,5-dimethylfuran-2(5H)-ylidene)-4-methylbenzenesulfonamide 1 (C15H18BrNO4S) has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2, and characterized by mp, IR, 1H NMR, EIMS, ESIHRMS and single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/c with a = 11.714(5), b = 14.106(5), c = 10.402(4)(A), β = 97.298(8)°, V=1704.9(12)(A)3, Mr = 388.27, Z = 4, Dc = 1.513 g/cm3,μ(MoKα) = 2.549 mm-1, F(000) = 792, the final R = 0.033 and wR = 0.062 for 3098 observed reflections (Ⅰ＞ 2σ(Ⅰ)). |
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| Keywords: | synthesis crystal structure N-(4-bromo-5-ethoxy-3,5-dimethylfuran-2(SH)-ylidene)-4-methylbenzenesulfonamide anticancer |
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