| Abstract: | New ONS Ligands and their Zinc Complexes with Relation to the Zinc Enzyme Alcoholdehydrogenase By ring opening of dimethyl thiirane with ethanolamine or by Schiff base condensation between salicylic aldehydes and 2‐mercaptoisobutylamine the tridentate ONS ligands H2MIEA, H2MIIMP, and H2MIIMTP were obtained. The former yielded the zinc complex (MIEA)Zn(ethanolamine) ( 1 ) with a trigonal bipyramidal ZnO2N2S coordination. The latter two and ZnN(SiMe3)2]2 yielded the presumably dimeric complexes Zn(MIIMP) and Zn(MIIMTP) ( 2 a , b ). Benzoyl pyridine and phenylhydroxymethylpyridine as bidentate coligands L could be combined with H2MIIMP in the complexes L · Zn(MIIMP) ( 3 , 4 ) whose ZnO2N2S coordination corresponds to that of 1 . Partial hydrolytic degradation led to the unusual trinuclear complex 5 which contains, inter alia, the condensation product of the salicylic aldimine and benzoyl pyridine as a ligand. The complexes obtained and the coordination patterns observed represent new structural analogies with the environment of zinc in the enzyme horse liver alcoholdehydrogenase. |
