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NMR structural study of hydrogels based on partially deacetylated hyaluronan |
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| Authors: | Vittorio Crescenzi Andrea Francescangeli Anna Laura Segre Donatella Capitani Luisa Mannina Davide Renier Davide Bellini |
| Affiliation: | 1. Department of Chemistry, University “La Sapienza”, Rome, Italy;2. Institute of Chemical Methodologies, CNR, Research Area of Rome, Monterotondo stazione (RM), Italy;3. Institute of Chemical Methodologies, CNR, Research Area of Rome, Monterotondo stazione (RM), Italy S.T.A.T. Department, University of Molise, Isernia, Italy;4. “Fidia Advanced Biopolymers”, FAB, Srl, Abano Terme (PD), Italy |
| Abstract: | Hydrogels have been prepared using two partially deacetylated hyaluronan (deHA) samples having a molar ratio of free amino groups to total initial N-acetamido groups equal to 23 and 33%, respectively. Taking advantage of such primary amino functionalities, polymeric networks could be easily obtained in aqueous media by means of two different crosslinking procedures, namely: a) Ugi multicomponent reactions and, more simply, b) glutaraldehyde reticulation. In this paper, we wish to report on the synthesis of deHA based hydrogels and, in particular, on their structural elucidation as obtained by NMR studies.  Structure of HA (R = COCH3) and de-HA (R = H) repeat units. |
| Keywords: | CP-MAS NMR glutaraldehyde hyaluronic acid hydrogels NMR Ugi's reaction |