Synthesis of well-defined chain-end- and in-chain-functionalized polystyrenes with a definite number of benzyl chloride moieties and D-glucose residues |
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Authors: | Akira Hirao Mayumi Hayashi Yumi Negishi Naoki Haraguchi Surapich Loykulnant |
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Affiliation: | Polymeric and Organic Materials Department, Graduate School of Science and Technology, Tokyo Institute of Technology, 2-12-1, Ohokayama, Meguro-ku, Tokyo 152-8552, Japan |
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Abstract: | Novel well-defined chain-end- and in-chain-functionalized polystyrenes with six, eight, twelve, and sixteen benzyl chloride moieties and with four and eight D-glucose residues have been successfully synthesized by developing the methodology based on living anionic polymerization of using new functionalized agents derived from functionalized 1,1-diphenylethylene (DPE) derivatives. They are 1,10-dichloro-4,4-7,7-tetra(3-methoxymethylphenyl)decane, its iodide derivative, the dianion prepared from 1,1-bis(3-methoxymethylphenyl)ethylene and potassium naphthalenide, and 1,1-bis[3′,5′-bis(1,2:5,6-di-O-isopropylidene-α-D-glucofuranose-3-oxymethyl)phenyl]ethylene. The developed methodology involves diverse modes of reactions of polystyryllithium with new functionalized agents and either the subsequent transformation reaction with BCl3 into benzyl chloride moieties or acid-hydrolysis to regenerate D-glucose residues. The resulting chain-multi-functionalized polystyrenes were precisely controlled with respect to chain length and quantitatively functionalized within experimental errors. |
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