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Charge transfer in duplex DNA containing mismatch |
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| Authors: | Akira Okada Satoshi Yokojima Noriyuki Kurita Yasuo Sengoku Shigenori Tanaka |
| Institution: | a Institute of Materials Science, University of Tsukuba, Tsukuba 305-8573, Japan b Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguchi 332-0012, Japan c Department of Knowledge-Based Information Engineering, Toyohashi University of Technology, Tempoaku-cho, Toyohashi 441-8580, Japan d Advanced Materials and Devices Laboratory, Corporate Research and Development Center, Toshiba Corporation, 1 Komukai Toshiba-cho, Saiwai-ku, Kawasaki 212-8582, Japan |
| Abstract: | A theory for charge transfer between the electrode and the donor/acceptor molecule coupled through a DNA bridge in solution is developed. We explore the crossover between the coherent tunneling and the incoherent sequential transfer regimes by varying the electrode potential and discuss the effects of single-base mismatches in DNA duplex in both regimes. In the former regime a single-base mismatch in DNA duplex causes a reduction in the charge transfer rate simply by decreasing the electron tunneling matrix element, however, in the latter regime the effects are rather complicated. |
| Keywords: | DNA Electron transfer Charge transfer Electrochemistry |
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