| Studies on the Voltammetric Behavior of Nicardipine Hydrochloride and its Voltammetric Determination at the Co/GC Modified Electrode |
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| 作者姓名： | ZHI Yao HU Jingbo and LI Qilong** |
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| 作者单位： | ZHI Yao，HU Jingbo and LI Qilong**
(Department of Chemistry，Beijing Normal University，Beijing，100875) HUANG Qingquan
(National Institute for the Control of Pharmaceutical and Biological Products，Beijing，100050) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｔｅｃｈｎｉｑｕｅｏｆｉｏｎｉｍｐｌａｎｔａｔｉｏｎｈａｓｂｅｅｎｄｅｖｅｌｏｐｅｄａｓａｍｅａｎｓｏｆｉｎｔｒｏｄｕｃｔｉｎｇｆｏｒｅｉｇｎａｔｏｍｓｉｎｔｏｔｈｅｓｕｒｆａｃｅｌａｙｅｒｓｏｆａｓｏｌｉｄ．Ｔｈｉｓｔ...
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Studies on the Voltammetric Behavior of Nicardipine Hydrochloride and its Voltammetric
Determination at the Co/GC Modified Electrode* |
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| ZHI Yao,HU Jingbo and LI Qilong**.Studies on the Voltammetric Behavior of Nicardipine Hydrochloride and its Voltammetric Determination at the Co/GC Modified Electrode[J].Chemical Research in Chinese University,1999(2). |
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| Authors: | ZHI Yao HU Jingbo and LI Qilong |
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| Institution: | ZHI Yao,HU Jingbo and LI Qilong** |
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| Abstract: | To whom correspondence should be addressed. In a 002 mol/L BR buffer
solution(pH=552), the electrochemical behaviour of nicardipine hydrochloride was studied by
linearsweep voltammetry and cyclic voltammetry at a Co/GC ion implantation modified
electrode. The experiments showed that the electrode had a good stability and reproductivity.
The peak height was proportional to the concentration of nicardipine over the range of
4010-71010-4 mol/L and the detection limit was 1010-7 mol/L. This method has been used for
the direct determination of nicardipine in tablets. Its recoveries were in the range from 956% to
1038%. The reduction of nicardipine at the Co/GC electrode was an irreversible proccess. |
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| Keywords: | Ion implantation Modified electrode Nicardipine Linearsweep voltammetry |
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