| 4-溴-5-甲基靛红的Baeyer-Villiger氧化反应 |
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| 引用本文： | 陈卫民,曾陇梅. 4-溴-5-甲基靛红的Baeyer-Villiger氧化反应[J]. 高等学校化学学报, 1999, 20(3): 421-423 |
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| 作者姓名： | 陈卫民 曾陇梅 |
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| 作者单位： | 1. 第一军医大学药物研究所, 广州 510515;2. 中山大学化学与化学工程学院, 广州 510275 |
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| 摘 要： | Baeyer-Viliger反应是由酮制备酯的重要方法[1].氧化剂通常有两类:(1)有机过酸;(2)过硫酸钾/硫酸(Caro酸).由于靛红结构特殊,我们分别以单过邻苯二甲酸[2]和过硫酸钾/硫酸[3]为氧化剂氧化4-溴-5-甲基靛红(1).
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| 关 键 词： | 4-溴-5-甲基靛红 氧化 Baeyer-Villiger反应 |
| 收稿时间： | 1998-05-08 |
| 修稿时间： | 1998-05-08 |
Baeyer-Villiger Oxidation of 4-Bromo-5-methylisatin |
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| CHEN Wei-Min,ZENG Long-Mei. Baeyer-Villiger Oxidation of 4-Bromo-5-methylisatin[J]. Chemical Research In Chinese Universities, 1999, 20(3): 421-423 |
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| Authors: | CHEN Wei-Min ZENG Long-Mei |
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| Affiliation: | 1. Institute of Pharmaceutical Sciences, The First Military Medical University, Guangzhou, 510515;2. Department of Chemistry, Zhongshan University, Guangzhou, 510275 |
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| Abstract: | Two different products were obtained while 4bromo5methylisatin was oxidized by separately using organic peroxy acids and Caros acid as the oxidizing agent. The chemical structures of the oxidation products were elucidated by spectra analysis to be a pair of {isomer}: novel compound 5bromo6methyl1Hbenzo oxazine2,3dione and the known compound 5bromo6methyl1Hbenzo oxazine2,4dione. The product is free of isomer for each reaction. The reaction mechanisms were also discussed. |
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| Keywords: | Bromo5methylisatin Oxidation BaeyerVilliger reaction |
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