| 速溶电纺载药PVP纳米纤维膜制备与表征 |
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| 引用本文： | 余灯广,申夏夏,张晓飞,朱利民.速溶电纺载药PVP纳米纤维膜制备与表征[J].高分子学报,2009,0(11):1170-1174. |
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| 作者姓名： | 余灯广 申夏夏 张晓飞 朱利民 |
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| 作者单位： | 1. 东华大学化学化工与生物工程学院,上海,201620
2. 伦敦都市大学卫生健康与政策研究所,伦敦,N78DB,UK |
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| 基金项目： | London Metropolitan University-东华大学中英药用纺织品联合实验室、上海市科委基金,中国博士后科学基金 |
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| 摘 要： | 采用电纺工艺制备载豆腐果苷聚乙烯基吡咯烷酮纳米纤维膜.通过偏光显微镜确定电纺条件,利用扫描电镜对纤维膜表面形态进行观察;采用X-射线晶体衍射(XRD)和差示扫描量热分析(DSC)检测纤维膜中药物的存在状态,通过红外光谱分析药物与纤维基材之间的相互作用.结果表明载药纤维直径分布均匀(400~600 nm)、表面光滑无药物颗粒,药物与聚合物之间通过氢键作用、具有良好的相容性,XRD和DSC结果表明药物以无定形态高度分散于纳米纤维中,纤维膜中药物以"聚合物控释"机制在13.7 s左右完全溶解.
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| 关 键 词： | 电纺 载药纳米纤维 聚乙烯基吡咯烷酮 速溶 难溶药物 |
| 收稿时间： | 2009-04-21 |
PREPARATION AND CHARACTERIZATION OF FAST-DISSOLVING ELECTROSPUN DRUG-LOADED PVP NANOFIBER MEMBRANES |
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| YU Dengguang,SHEN Xiaxia,ZHANG Xiaofei,Branford-White Chris,ZHU Limin.PREPARATION AND CHARACTERIZATION OF FAST-DISSOLVING ELECTROSPUN DRUG-LOADED PVP NANOFIBER MEMBRANES[J].Acta Polymerica Sinica,2009,0(11):1170-1174. |
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| Authors: | YU Dengguang SHEN Xiaxia ZHANG Xiaofei Branford-White Chris ZHU Limin |
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| Institution: | College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620; Institute for Health Research and Policy, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK |
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| Abstract: | Drug-loaded nanofiber membrane was successfully prepared using electrospinning process with helicid as the poorly water-soluble model drug and polyvinylpyrrolidone(PVP K30) as the filament-forming matrix.Polarization microscopy(PM) and scanning electron microscopy(SEM) were taken to observe the morphology and structure of the nanofibers.Differential scanning calorimetry(DSC) and X-ray diffraction(XRD) were carried out to determine the physical status of the drug in the nanofibers.Fourier-transform infrared ... |
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| Keywords: | Electrospinning Drug-loaded nanofibers Polyvinylpyrrolidone Fast dissolving Poorly water-soluble drug |
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