Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development |
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| Authors: | Xiu-Li Kuang Xiao-Mei Zhao Hai-Fang Xu Yuan-Yuan Shi Jin-Bo Deng Guo-Tao Sun |
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| Affiliation: | 1.Department of Biochemistry and Molecular Biology,Institute of Neurobiology, Medical School, Henan University,KaiFeng,PR China;2.Department of Biochemistry and Molecular Biology,Institute of Molecular Medicine, Medical School, Henan University,KaiFeng,PR China |
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| Abstract: | Background Neuron-derived neurotrophic factor (NDNF) is evolutionarily well conserved, being present in invertebrate animals such as the nematode, Caenorhabditis elegans, as well as in the fruit fly, Drosophila melanogaster. Multiple cysteines are conserved between species and secondary structure prediction shows that NDNF is mainly composed of beta-strands. In this study, we aimed to investigate the function of NDNF. |
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