Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons |
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| Authors: | Jun Zhong Theresa Zhang Lisa M Bloch |
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| Institution: | (1) Department for Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 29, Brooklyn, NY 11203, USA;(2) Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA;(3) Agilent Technologies, Integrated Biology Systems, 1 Cragwood Road, South Plainfield, NJ 07080, USA |
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| Abstract: | Background Targeted transport of messenger RNA and local protein synthesis near the synapse are important for synaptic plasticity. In
order to gain an overview of the composition of the dendritic mRNA pool, we dissected out stratum radiatum (dendritic lamina)
from rat hippocampal CA1 region and compared its mRNA content with that of stratum pyramidale (cell body layer) using a set
of cDNA microarrays. RNAs that have over-representation in the dendritic fraction were annotated and sorted into function
groups. |
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