Catalytic asymmetric silane alcoholysis: practical access to chiral silanes |
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| Authors: | Schmidt Darby R O'Malley Steven J Leighton James L |
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| Affiliation: | Department of Chemistry, Columbia University, New York, New York 10027, USA. |
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| Abstract: | A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated. |
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