A New Crystal Structure of Clarithromycin |
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Authors: | Jian-Hua Liang Guo-Wei Yao |
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Institution: | (1) School of Life Science and Technology, Beijing Institute of Technology, Beijing, 100081, China |
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Abstract: | Abstract A new crystal structure of clarithromycin single acetonitrile solvate designated “Form III” was first determined by single
crystal X-ray diffraction. The compound crystallized in the monoclinic system, P2
1
space group with a = 10.644(2) ?, b = 18.099(4) ?, c = 11.628(2) ?, α = γ = 90°, β = 95.38(3)°, V = 2230.1(8) ?3, Z = 2, D
c = 1.175 g/cm3, μ = 0.087 mm−1, F(000) = 860, R
1 = 0.034, wR
2 = 0.062, S = 0.875, (Δ/σ)max = 0.001 for 2,709 observed reflections (I > 2σ (Ι)). Form III of clarithromycin, contrary to Form I, is more thermodynamically stable than Form II used currently on the market.
Graphical abstract
A New Crystal Structure of Clarithromycin
Jian-Hua Liang, Guo-Wei Yao
A crystal structure of clarithromycin single acetonitrile solvate was first determined by single crystal X-ray diffraction.
![MediaObjects/10870_2007_9287_Figa_HTML.gif](/content/e50682162607177m/MediaObjects/10870_2007_9287_Figa_HTML.gif) |
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Keywords: | Clarithromycin Single crystal Regioselectivity Form III |
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