Particle circulation and oxygen mass transfer in an immobilized cell bioreactor |
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Authors: | Dean Jonathan F Webb Colin |
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Institution: | (1) Department of Chemical Engineering, U.M.I.S. T., M60 1QD Manchester, England |
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Abstract: | Two important considerations in the design of an aerobic particulate immobilized cell bioreactor are the provision of sufficient
oxygen to maintain the desired metabolism of the immobilized organism, and the biomass holdup (which is proportional to the
number of immobilized cell particles in the reactor).
The Circulating Bed Reactor, a reactor developed for use with those forms of immobilization that result in particles of essentially
neutral buoyancy, operates with an expanded bed of circulating particles. The particle number density attainable in such a
reactor has been found to be dependent upon the circulation cell aspect ratio, the individual particle properties, the static
bed voidage of the particles, and the superficial gas velocity. The oxygen mass transfer characteristics have been found to
be dependent upon the circulatory nature of the system, the particle (solids) holdup, the particle porosity, and the superficial
gas velocity. |
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Keywords: | Particle circulation in an immobilized cell bioreactor oxygen mass transfer in an immobilized cell bioreactor |
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