Reactions of aromatic and heteroaromatic compounds carrying electron-acceptor substituents. 26. Acylaminomethylation of 2-acylthiophenes, 2-thiophenecarboxylic acid,and its esters |
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Authors: | Ya. L. Gol'dfarb A. P. Yakubov L. I. Belen'kii |
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Affiliation: | (1) N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, 117913 Moscow |
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Abstract: | The reaction of 2-thiophene aldehyde, 2-acetylthiophene, 2-thiophene carboxylic acid, and its methyl ester with N-(hydroxymethyl)chloroacetamide in concentrated sulfuric acid yields a mixture of 4- and 5-(N-chloroacetylamino) methyl derivatives, the former being preferred.For Communication 25, see [1].Deceased.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 793–797, June, 1986. |
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