Anti-diabetes effect of Zn(II)/carnitine complex by oral administration |
| |
Authors: | Yoshikawa Yutaka Ueda Eriko Sakurai Hiromu Kojima Yoshitane |
| |
Affiliation: | Department of Chemistry, Graduate School of Science, Osaka City University, Japan. |
| |
Abstract: | A novel bis(L-carnitinato)Zn(II) complex, Zn(car)(2)Cl(2), was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|