| 一种合成3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶的新路线 |
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| 引用本文： | 胡炳成,梁长玉,陆明,戴红升,孙呈郭,徐士超.一种合成3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶的新路线[J].应用化学,2012,29(1):80-83. |
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| 作者姓名： | 胡炳成 梁长玉 陆明 戴红升 孙呈郭 徐士超 |
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| 作者单位： | (南京理工大学化工学院 南京 210094) |
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| 基金项目： | 国家部委基金，国家自然科学基金委员会和中国工程物理研究院联合基金 |
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| 摘 要： | 以3,5-二甲基吡啶为起始原料，经氧化、酰胺化，酰胺在不同的霍夫曼降解条件下合成3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶，总收率分别为64%和68%。利用1H NMR、MS/MS、IR等方法对各化合物的结构进行了表征。讨论了氧化反应及霍夫曼降解反应的主要影响因素。反应均在常压下进行，反应条件温和，后处理简单，效率高。
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| 关 键 词： | 二甲基吡啶 霍夫曼降解 二氨基吡啶 二甲氧羰基氨基吡啶 合成 |
| 收稿时间： | 2011-02-21 |
| 修稿时间： | 2011-04-08 |
A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine |
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| HU Bingcheng
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LIANG Changyu
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LU Ming
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DAI Hongsheng
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SUN Chengguo
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XU Shichao.A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine[J].Chinese Journal of Applied Chemistry,2012,29(1):80-83. |
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| Authors: | HU Bingcheng LIANG Changyu LU Ming DAI Hongsheng SUN Chengguo XU Shichao |
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| Institution: | (School of Chemical Engineering,Nanjing University of Science & Technology,Nanjing 210094) |
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| Abstract: | 3,5-Diaminopyridine and 3,5-dimethoxycarbonylamino-pyridine were prepared from 3,5-dimethylpyridine in three steps including oxidation of methyl,amination and Hofmann degradation with the total yield of 64% and 68%,respectively.The reaction conditions of every step were studied and the intermediates and target compounds were characterized by 1H NMR,MS/MS,and IR.The reactions proceed under atmosphere pressure with mild reaction conditions,easy post treatment and high efficiency. |
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| Keywords: | dimethylpyridine Hofmann degradation diaminopyridine dimethoxycarbonylamino-pyridine |
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