| 超声法合成3,4-二甲氧基-4'-羟基查尔酮 |
| |
| 引用本文： | 杨洁,李立忠,申凤善,李香丹. 超声法合成3,4-二甲氧基-4'-羟基查尔酮[J]. 应用化学, 2012, 29(6): 724-726. DOI: 10.3724/SP.J.1095.2012.00385 |
| |
| 作者姓名： | 杨洁 李立忠 申凤善 李香丹 |
| |
| 作者单位： | (1.中南民族大学化学与材料科学学院 武汉 430074；2.延边大学理学院 延吉 133002) |
| |
| 基金项目： | 湖北省自然科学基金资助项目 |
| |
| 摘 要： | 以3,4-二甲氧基-苯甲醛和对羟基苯乙酮为原料，无水乙醇为溶剂，HCl气体为催化剂，在超声作用下，经Claisen-Schmidt缩合反应合成了3,4-二甲氧基-4′-羟基查尔酮。 产物结构经IR和1H NMR进行了表征，在2种原料摩尔比1∶1投料比条件下，优化的合成条件为超声输出功率240 W,反应温度30 ℃，反应时间20 min，产率达到92.1%，比传统方法反应时间短、操作简便、产率高。
|
| 关 键 词： | 二甲氧基羟基查尔酮 超声波 合成 |
| 收稿时间： | 2011-09-01 |
| 修稿时间： | 2011-11-30 |
Synthesis of 3, 4-Dimethoxy-4’-hydroxychalcone by ultrasound |
| |
| YANG Jie , LI Lizhong , SHEN Fengshan , LI Xiangdan. Synthesis of 3, 4-Dimethoxy-4’-hydroxychalcone by ultrasound[J]. Chinese Journal of Applied Chemistry, 2012, 29(6): 724-726. DOI: 10.3724/SP.J.1095.2012.00385 |
| |
| Authors: | YANG Jie LI Lizhong SHEN Fengshan LI Xiangdan |
| |
| Affiliation: | (1.College of Chemistry and Materials Science,South-Central University for Nationalities,Wuhan 430074,China;2.College of Science,Yanbian University,Yanji 133400,China) |
| |
| Abstract: | 3,4-Dimethoxy-4′-hydroxychalcone was synthesized by the Claisen-Schmidt condensation using 3,4-dimethoxybenzaldehyde and 4′-hydroxyacetophenone as reagents with ultrasonic radiation and dry HCl(g) as catalyst.The structure of the product was confirmed by IR and 1H NMR.The optimized synthesis conditions were to use anhydrous ethanol as the solvent,reaction temperature of 30 ℃,ultrasonic radiation of 240 W,and radiation time of 20 min.A yield of 92.1% was obtained for the reaction with 1∶ 1 stoichiometric ratio for the starting materials.Compared with previous method in the literature,the present procedure requires a shorter reaction time,and has easier work-up and higher yield. |
| |
| Keywords: | dimethoxyhydroxy chalcone ultrasound synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
|
点击此处可从《应用化学》下载全文 |
|
