Cyclosporin A increases recovery after spinal cord injury but does not improve myelination by oligodendrocyte progenitor cell transplantation |
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| Authors: | He-Zuo Lü Yan-Xia Wang Jian-Sheng Zhou Feng-Chao Wang Jian-Guo Hu |
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| Affiliation: | 1.Central Laboratory,the First Affiliated Hospital of Bengbu Medical College,Anhui,China;2.Anhui Key Laboratory of Tissue Transplantation,Bengbu Medical College,Anhui,China;3.Department of Neurobiology,Shanghai Jiaotong University School of Medicine,Shanghai,China;4.Department of Clinical Laboratory Science,the First Affiliated Hospital of Bengbu Medical College,Anhui,China |
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| Abstract: | Background Transplantation of oligodendrocyte precursor cells (OPCs) is an attractive therapy for demyelinating diseases. Cyclosporin A (CsA) is one of the foremost immunosuppressive agents and has widespread use in tissue and cell transplantation. However, whether CsA affects survival and differentiation of engrafted OPCs in vivo is unknown. In this study, the effect of CsA on morphological, functional and immunological aspects, as well as survival and differentiation of engrafted OPCs in injured spinal cord was explored. |
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